{"id":272,"date":"2024-08-30T12:48:01","date_gmt":"2024-08-30T03:48:01","guid":{"rendered":"http:\/\/raychief7.synology.me:7307\/?page_id=272"},"modified":"2024-08-30T12:58:56","modified_gmt":"2024-08-30T03:58:56","slug":"%ea%b7%bc%ea%b8%b4%ec%9e%a5%ec%84%b1-%ec%9d%b4%ec%98%81%ec%96%91%ec%a6%9dmyotonic-dystrophy-%eb%9e%80","status":"publish","type":"page","link":"http:\/\/mdt1f.org\/?page_id=272","title":{"rendered":"\uadfc\uae34\uc7a5\uc131 \uc774\uc601\uc591\uc99d (Myotonic Dystrophy) \uc124\uba85"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\uac1c\uc694<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\uadfc\uae34\uc7a5\uc131 \uc774\uc601\uc591\uc99d(DM) \uc740 \uc720\uc804 \uc9c8\ud658\uc73c\ub85c, \uadfc\uc721\uc758 \uc218\ucd95\uacfc \uc774\uc644\uc5d0 \uc5b4\ub824\uc6c0\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \uc774 \uc9c8\ud658\uc740 \uc8fc\ub85c <strong>DMPK<\/strong> \uc720\uc804\uc790\uc758 <strong>CTG \ubc18\ubcf5 \ud655\uc7a5<\/strong>\uc73c\ub85c \uc778\ud574 \ubc1c\uc0dd\ud558\uba70, \uc720\uc804\uc790\uac00 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uae34 \ubc18\ubcf5 \uc11c\uc5f4\uc744 \uac00\uc9c0\uac8c \ub429\ub2c8\ub2e4.<\/p>\n<cite>\uc804 \uc138\uacc4\uc801\uc73c\ub85c \uac00\uc7a5 \ud754\ud55c \uc720\uc804\uc131 \uadfc\uc721 \uc9c8\ud658 \uc911 \ud558\ub098\ub85c, \ub300\ub7b5 8,000\uba85\uc5d0\uc11c 20,000\uba85 \uc911 1\uba85 \uaf34\ub85c \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \ubd81\ubbf8\uc640 \uc720\ub7fd\uc5d0\uc11c \ub354 \uc790\uc8fc \ubc1c\uc0dd\ud558\uba70, \ub2e4\ub978 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ub354 \ub4dc\ubb38 \ud3b8\uc785\ub2c8\ub2e4. \ud2b9\ud788 DM1 \ud615\ud0dc\uac00 DM2\ubcf4\ub2e4 \ub354 \ud754\ud558\uac8c \ubcf4\uace0\ub418\uba70, \uc720\ubcd1\ub960\uc740 \uc778\uc885\uacfc \uc9c0\uc5ed\uc5d0 \ub530\ub77c \ucc28\uc774\uac00 \uc788\uc2b5\ub2c8\ub2e4.<br><br>\uc720\uc804\uc801 \ud2b9\uc131\uc0c1 \uac00\uc871 \ub0b4\uc5d0\uc11c \uc5ec\ub7ec \uc138\ub300\uc5d0 \uac78\uccd0 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc73c\uba70, \uc99d\uc0c1\uc758 \uc911\uc99d\ub3c4\uc640 \ubc1c\ubcd1 \uc5f0\ub839\uc740 \uac1c\uc778\uc5d0 \ub530\ub77c \ub2e4\ub985\ub2c8\ub2e4.<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\uc6d0\uc778<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\uadfc\uae34\uc7a5\uc131 \uc774\uc601\uc591\uc99d(DM)\uc740 19\ubc88 \uc5fc\uc0c9\uccb4\uc5d0 \uc704\uce58\ud55c <strong>DMPK (Myotonic Dystrophy Protein Kinase)<\/strong> \uc720\uc804\uc790\uc758 \ubcc0\uc774\ub85c \uc778\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uac01\uac01 \ubd80\ubaa8\ub85c\ubd80\ud130 \ud558\ub098\uc529 \ubc1b\uc740 \ub450 \uac1c\uc758 DMPK \uc720\uc804\uc790\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \uc774 \uc911 \ud558\ub098\uc5d0 \ubcc0\uc774\uac00 \uc0dd\uae30\uba74 DM\uc774 \ubc1c\ubcd1\ud558\uac8c \ub429\ub2c8\ub2e4. \uc774\ub294 <strong>\uc0c1\uc5fc\uc0c9\uccb4 \uc6b0\uc131 \uc720\uc804<\/strong> \uc9c8\ud658\uc73c\ub85c, \uc131\ubcc4\uc5d0 \uc0c1\uad00\uc5c6\uc774 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p>\uc5ec\uc131\uc774 DM \uc720\uc804\uc790\ub97c \uac00\uc9c0\uace0 \uc788\uc744 \uacbd\uc6b0, \uc790\ub140\uc5d0\uac8c \uc9c8\ud658\uc744 \uc804\uc218\ud560 \ud655\ub960\uc740 \uc784\uc2e0\ub9c8\ub2e4 50%\uc785\ub2c8\ub2e4. \uc790\ub140\uc758 \ubc1c\ubcd1 \uc5f0\ub839\uacfc \uc99d\uc0c1\uc740 \ubd80\ubaa8\uc640 \ub3d9\uc77c\ud560 \uc218\ub3c4 \uc788\uace0 \ub2e4\ub97c \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>CTG \ubc18\ubcf5 \ud69f\uc218\uc5d0 \ub530\ub978 \uc9c4\ud589<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>50~150\ud68c<\/strong>: \uc131\uc778\uae30\uc5d0 \uacbd\ubbf8\ud55c \uc99d\uc0c1. \uadfc\uc721 \uc57d\ud654\uac00 \uc11c\uc11c\ud788 \uc9c4\ud589\ub429\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>150~1,000\ud68c<\/strong>: \uccad\uc18c\ub144\uae30\uc5d0 \ubc1c\ubcd1, \uadfc\uc721 \uc57d\ud654\uac00 \ub354 \ub450\ub4dc\ub7ec\uc9c0\uace0 \uc2ec\uc7a5, \ud638\ud761\uae30 \ubb38\uc81c\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>1,000\ud68c \uc774\uc0c1<\/strong>: \uc120\ucc9c\uc131 DM\uc73c\ub85c, \uc2e0\uc0dd\uc544 \uc2dc\uae30\uc5d0 \uc2ec\uac01\ud55c \uadfc\uc721 \uc57d\ud654\uc640 \ub2e4\uae30\uad00 \uc190\uc0c1\uc774 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. \uc0dd\ud6c4 \ucd08\uae30\ubd80\ud130 \ud638\ud761\uae30 \ubc0f \uc2ec\uc7a5 \ubb38\uc81c\ub85c \uc778\ud574 \uc0dd\uba85\uc774 \uc704\ud0dc\ub85c\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ul>\n<cite><strong>CTG \ubc18\ubcf5 \ud655\uc7a5<\/strong>: \uc815\uc0c1\uc801\uc778 \uacbd\uc6b0 CTG \ubc18\ubcf5\uc740 5~34\ud68c \uc815\ub3c4\uc774\uc9c0\ub9cc, DM\uc5d0\uc11c\ub294 \uc774 \ubc18\ubcf5\uc774 50\ud68c\uc5d0\uc11c \ucd5c\ub300 \uc218\ucc9c \ud68c\uae4c\uc9c0 \ub298\uc5b4\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br><br><strong>\ub3c5\uc131 RNA<\/strong>: \ud655\uc7a5\ub41c CTG \ubc18\ubcf5\uc740 \uc720\uc804\uc790\uc5d0\uc11c \ube44\uc815\uc0c1\uc801\uc778 RNA\ub97c \ub9cc\ub4e4\uace0, \uc774 RNA\uac00 \uc138\ud3ec \ub0b4 \ub2e8\ubc31\uc9c8\uacfc \uacb0\ud569\ud558\uc5ec \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4.<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\uc784\uc0c1\uc99d\uc0c1<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><strong>DM\uc758 \uc8fc\uc694 \ud2b9\uc9d5<\/strong>:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\uadfc\uae34\uc7a5\uc99d(Myotonia)<\/strong>: \uadfc\uc721\uc774 \uc218\ucd95 \ud6c4 \uc774\uc644\ub418\ub294 \ub370 \uc2dc\uac04\uc774 \uac78\ub9ac\ub294 \ud604\uc0c1\uc73c\ub85c, \ubb38\uace0\ub9ac\ub098 \ucef5 \uac19\uc740 \ubb3c\uac74\uc744 \ub193\ub294 \ub370 \uc5b4\ub824\uc6c0\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \ubaa8\ub4e0 \ud658\uc790\uac00 \uadfc\uae34\uc7a5\uc99d\uc744 \uacaa\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4.\uadfc\uc721\uc774 \uc218\ucd95 \ud6c4 \uc774\uc644\ud558\ub294 \ub370 \uc5b4\ub824\uc6c0\uc744 \uacaa\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc8fc\uba39\uc744 \uc954 \ud6c4 \ud3b4\ub294 \uac83\uc774 \uc5b4\ub835\uc2b5\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\uc548\uba74\uadfc\uc721 \uc57d\ud654<\/strong>: \uac00\uc7a5 \ucd08\uae30\uc5d0 \ub098\ud0c0\ub098\ub294 \uc99d\uc0c1\uc73c\ub85c, \ud718\ud30c\ub78c\uc744 \ubd88\uac70\ub098 \ube68\ub300\ub97c \uc0ac\uc6a9\ud558\ub294 \ub370 \uc5b4\ub824\uc6c0\uc774 \uc788\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc548\uac80\ud558\uc218(\ub208\uaebc\ud480 \ucc98\uc9d0)\uc640 \ud131\uadfc\uc721 \uc57d\ud654\ub3c4 \ud754\ud788 \ub098\ud0c0\ub0a9\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\uadfc\uc721 \uc57d\ud654<\/strong>: \uc8fc\ub85c \uc190\uacfc \ubc1c\uc758 \uadfc\uc721\uc5d0\uc11c \uc2dc\uc791\ub418\uba70, \uc77c\uc0c1\uc801\uc778 \uc791\uc5c5\uc5d0 \uc5b4\ub824\uc6c0\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \ubc1c\ubaa9 \uc57d\ud654\ub85c \uc778\ud55c \ubd88\uc548\uc815\ud55c \uac78\uc74c\uac78\uc774\ub3c4 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n<ul class=\"wp-block-list\"><\/ul>\n<\/li>\n\n\n\n<li><strong>\uc2ec\uc7a5 \ubb38\uc81c<\/strong>: \uc2ec\uc7a5 \ubc15\ub3d9 \ubd88\uaddc\uce59, \uc2ec\ubd80\uc804 \ub4f1\uc758 \ubb38\uc81c\uac00 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\ub0b4\ubd84\ube44 \ubb38\uc81c<\/strong>: \ub2f9\ub1e8\ubcd1, \uac11\uc0c1\uc120 \uae30\ub2a5 \uc800\ud558 \ub4f1\uacfc \uac19\uc740 \ub0b4\ubd84\ube44 \uc7a5\uc560\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\ubc31\ub0b4\uc7a5<\/strong>: \ub208\uc758 \ubc31\ub0b4\uc7a5\uc774 \uc870\uae30 \ubc1c\ubcd1\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ol>\n\n\n\n<p><strong>\ubc1c\ubcd1 \uc5f0\ub839\uc5d0 \ub530\ub978 DM \uc720\ud615<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\uc120\ucc9c\uc131 DM<\/strong>: \ucd9c\uc0dd \ud6c4 1\ub2ec \ub0b4\uc5d0 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uba70, \ud638\ud761\uae30 \ubb38\uc81c\uc640 \uc9c0\ub2a5 \uc800\ud558\uac00 \ub3d9\ubc18\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5b4\uba38\ub2c8\uac00 DM \ud658\uc790\uc778 \uacbd\uc6b0 \ubc1c\uc0dd \ud655\ub960\uc774 \ub192\uc2b5\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\uccad\uc18c\ub144\uae30 DM<\/strong>: 1\uc138\uc5d0\uc11c 20\uc138 \uc0ac\uc774\uc5d0 \ubc1c\ubcd1\ud558\uba70, \uadfc\uc721 \uc57d\ud654\uc640 \uadfc\uae34\uc7a5\uc99d\uc774 \ud2b9\uc9d5\uc785\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\uc804\ud615\uc801 DM<\/strong>: 20\uc138\uc5d0\uc11c 40\uc138 \uc0ac\uc774\uc5d0 \ubc1c\ubcd1\ud558\uba70, \uccad\uc18c\ub144\uae30\uc640 \uc720\uc0ac\ud55c \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a9\ub2c8\ub2e4.<\/li>\n\n\n\n<li><strong>\ud6c4\ubc18\uae30 DM<\/strong>: 40\uc138 \uc774\ud6c4\uc5d0 \ubc1c\ubcd1\ud558\uba70, \uc8fc\ub85c \ubc31\ub0b4\uc7a5\uacfc \uacbd\ubbf8\ud55c \uacbd\ub828\uc744 \ub3d9\ubc18\ud558\uc9c0\ub9cc, \uadfc\uc721 \ubb38\uc81c\ub294 \ub35c \ub098\ud0c0\ub0a9\ub2c8\ub2e4.<\/li>\n<\/ul>\n\n\n\n<p>\ubc1c\ubcd1 \uc5f0\ub839\uc774 \ub0ae\uc744\uc218\ub85d \uc9c8\ud658\uc758 \uc911\uc99d\ub3c4\uac00 \ub354 \uc2ec\uac01\ud55c \uacbd\ud5a5\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\uc9c4\ub2e8 \ubc0f \uad00\ub9ac<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\uc9c4\ub2e8<\/strong>: \uadfc\uc804\ub3c4(EMG) \uac80\uc0ac, \uc720\uc804\uc790 \uac80\uc0ac \ub4f1\uc744 \ud1b5\ud574 \uc9c4\ub2e8\uc774 \uc774\ub8e8\uc5b4\uc9d1\ub2c8\ub2e4. EMG\ub97c \ud1b5\ud574 \uadfc\uae34\uc7a5\uc99d\uc744 \ud655\uc778\ud558\uace0, \uc720\uc804\uc790 \uac80\uc0ac\ub97c \ud1b5\ud574 CTG \ubc18\ubcf5 \ud655\uc7a5\uc758 \ud06c\uae30\ub97c \uce21\uc815\ud569\ub2c8\ub2e4.<br><\/li>\n\n\n\n<li><strong>\uad00\ub9ac \ubc0f \uce58\ub8cc<\/strong>: \ud604\uc7ac DM\uc758 \uadfc\ubcf8\uc801\uc778 \uce58\ub8cc\ubc95\uc740 \uc5c6\uc9c0\ub9cc, \uc99d\uc0c1 \uc644\ud654\ub97c \uc704\ud55c \uce58\ub8cc\uac00 \uac00\ub2a5\ud569\ub2c8\ub2e4. \ubb3c\ub9ac\uce58\ub8cc, \uc2ec\uc7a5 \ubaa8\ub2c8\ud130\ub9c1, \uc57d\ubb3c \uce58\ub8cc \ub4f1\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \uc720\uc804\uc790 \uce58\ub8cc\uc640 \uac19\uc740 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc774 \uc5f0\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\uac1c\uc694 \uadfc\uae34\uc7a5\uc131 \uc774\uc601\uc591\uc99d(DM) \uc740 \uc720\uc804 \uc9c8\ud658\uc73c\ub85c, \uadfc\uc721\uc758 \uc218\ucd95\uacfc \uc774\uc644\uc5d0 \uc5b4\ub824\uc6c0\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4. \uc774 \uc9c8\ud658\uc740 \uc8fc\ub85c DMPK \uc720\uc804\uc790\uc758 CTG \ubc18\ubcf5 \ud655\uc7a5\uc73c\ub85c \uc778\ud574 \ubc1c\uc0dd\ud558\uba70, \uc720\uc804\uc790\uac00 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uae34 \ubc18\ubcf5 \uc11c\uc5f4\uc744 \uac00\uc9c0\uac8c \ub429\ub2c8\ub2e4. \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uac00\uc7a5 \ud754\ud55c \uc720\uc804\uc131 \uadfc\uc721 \uc9c8\ud658 \uc911 \ud558\ub098\ub85c, \ub300\ub7b5 8,000\uba85\uc5d0\uc11c 20,000\uba85 \uc911 1\uba85 \uaf34\ub85c \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \ubd81\ubbf8\uc640 \uc720\ub7fd\uc5d0\uc11c \ub354 \uc790\uc8fc \ubc1c\uc0dd\ud558\uba70, \ub2e4\ub978 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \ub354 \ub4dc\ubb38 \ud3b8\uc785\ub2c8\ub2e4. \ud2b9\ud788 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-272","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/pages\/272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/mdt1f.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=272"}],"version-history":[{"count":2,"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/pages\/272\/revisions"}],"predecessor-version":[{"id":276,"href":"http:\/\/mdt1f.org\/index.php?rest_route=\/wp\/v2\/pages\/272\/revisions\/276"}],"wp:attachment":[{"href":"http:\/\/mdt1f.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}